Ivermectin you say

[J. Jackson]

Heard that in Australia they have found this drug to kill the virus in as little as 24 hrs. Already used for HIV and parasite treatments and used by vets as well. Said to need time to figure out dosages and more tests. With all the no-it-fuckingalls on here whats the deal? Behn will prolly respond first..

Edited April 5, 2020 by J. Jackson

[Jimmy Snacks]

Just now, J. Jackson said:

Heard that in Australia they have found this drug to kill the virus in as little as 24 hrs. Already used for HIV and parasite treatments and used by vets as well. Said to need time to figure out dosages and more tests. With all the no-it-fuckingalls on here whats the deal? Behn will prolly respond first..

I saw that article earlier...sounds promising. 

[steve from amherst]

Just now, J. Jackson said:

Heard that in Australia they have found this drug to kill the virus in as little as 24 hrs. Already use for HIV and parasite treatments and used by vets as well. Said to need time to figure out dosages and more tests. With all the no-it-fuckingalls on here whats the deal? Behn will prolly respond first..

There was a dude on NPR the other day that was on the frontlines of the original HIV outbreak who was saying some HIV drugs may work.

[spin_dry]

2 minutes ago, J. Jackson said:

Heard that in Australia they have found this drug to kill the virus in as little as 24 hrs. Already used for HIV and parasite treatments and used by vets as well. Said to need time to figure out dosages and more tests. With all the no-it-fuckingalls on here whats the deal? Behn will prolly respond first..

Several promising drugs. Probably no silver bullet until a vaccine though. 

[Zambroski]

3 minutes ago, steve from amherst said:

There was a dude on NPR the other day that was on the frontlines of the original HIV outbreak who was saying some HIV drugs may work.

"....for those assigned a gender at birth..."   

 

 

[steve from amherst]

1 minute ago, Zambroski said:

"....for those assigned a gender at birth..."   

 

 

I wasn't assigned anything at birth. I have a cock , so I know Im a dude.

[Zambroski]

Just now, steve from amherst said:

I wasn't assigned anything at birth. I have a cock , so I know Im a dude.

It's never too late to change you mind if you were "cheated" with assignment at birth.

[steve from amherst]

Just now, Zambroski said:

It's never too late to change you mind if you were "cheated" with assignment at birth.

If I didn't go back to work last week and went another month not working my tits would probably be big enough to fool some.

[Anler]

Let's here wut the no-it-allz have to say!

[1jkw]

 

Lets hope it works, it doesn't work well for worms anymore.

[Snake]

Abstract

Although several clinical trials are now underway to test possible therapies, the worldwide response to the COVID-19 outbreak has been largely limited to monitoring/containment. We report here that Ivermectin, an FDA-approved anti-parasitic previously shown to have broad-spectrum anti-viral activity in vitro, is an inhibitor of the causative virus (SARS-CoV-2), with a single addition to Vero-hSLAM cells 2 hours post infection with SARS-CoV-2 able to effect ∼5000-fold reduction in viral RNA at 48 h. Ivermectin therefore warrants further investigation for possible benefits in humans.

Ivermectin is an FDA-approved broad spectrum anti-parasitic agent1 that in recent years we, along with other groups, have shown to have anti-viral activity against a broad range of viruses2, 3, 4, 5 in vitro. Originally identified as an inhibitor of interaction between the human immunodeficiency virus-1 (HIV-1) integrase protein (IN) and the importin (IMP) α/β1 heterodimer responsible for IN nuclear import6, Ivermectin has since been confirmed to inhibit IN nuclear import and HIV-1 replication5. Other actions of ivermectin have been reported7, but ivermectin has been shown to inhibit nuclear import of host (eg.8,9) and viral proteins, including simian virus SV40 large tumour antigen (T-ag) and dengue virus (DENV) non-structural protein 55, 6. Importantly, it has been demonstrated to limit infection by RNA viruses such as DENV 1-44, West Nile Virus10, Venezuelan equine encephalitis virus (VEEV)3 and influenza2, with this broad spectrum activity believed to be due to the reliance by many different RNA viruses on IMPα/β1 during infection11,12. Ivermectin has similarly been shown to be effective against the DNA virus pseudorabies virus (PRV) both in vitro and in vivo, with ivermectin treatment shown to increase survival in PRV-infected mice13. Efficacy was not observed for ivermectin against Zika virus (ZIKV) in mice, but the authors acknowledged that study limitations justified re-evaluation of ivermectin’s anti-ZIKV activity14. Finally, ivermectin was the focus of a phase III clinical trial in Thailand in 2014-2017, against DENV infection, in which a single daily oral dose was observed to be safe and resulted in a significant reduction in serum levels of viral NS1 protein, but no change in viremia or clinical benefit was observed (see below)15.

The causative agent of the current COVID-19 pandemic, SARS-CoV-2, is a single stranded positive sense RNA virus that is closely related to severe acute respiratory syndrome coronavirus (SARS-CoV). Studies on SARS-CoV proteins have revealed a potential role for IMPα/β1 during infection in signal-dependent nucleocytoplasmic shutting of the SARS-CoV Nucleocapsid protein16, 17, 18, that may impact host cell division19,20. In addition, the SARS-CoV accessory protein ORF6 has been shown to antagonize the antiviral activity of the STAT1 transcription factor by sequestering IMPα/β1 on the rough ER/Golgi membrane21. Taken together, these reports suggested that ivermectin’s nuclear transport inhibitory activity may be effective against SARS-CoV-2.

https://www.sciencedirect.com/science/article/pii/S0166354220302011