XCR1250 Posted December 9, 2023 Share Posted December 9, 2023 An end to breast cancer? California company develops groundbreaking vaccine with promising future ASHLEY SHARP Updated December 8, 2023 at 10:54 AM Cleveland Clinic SACRAMENTO -- An estimated one in eight women will develop breast cancer in their lifetime, killing on average 42,000 women a year in the United States. What if there was a vaccine that would significantly lower each woman's chance of ever getting it in the first place? In that question lies what could be the answer to one day eliminating the deadly disease. A groundbreaking vaccine created through decades of research at the Cleveland Clinic and developed by Anixa Biosciences in San Jose, California is driving innovation by targeting triple-negative breast cancer, the disease's deadliest and most aggressive form. "This vaccine could potentially eliminate breast cancer," said Dr. Amit Kumar, Anixa CEO. The vaccine's findings from its first trial with 16 women were published Wednesday, with each participant reporting no bad side effects and no resurgence of their cancer so far. Jennifer Davis, a brave woman from small-town Ohio, was the first woman in the world to get the vaccine in October 2021. "This is how we advance medicine. It's important to be a part of those things," Davis said. "I am just beyond grateful." When Davis heard the dreaded words "you have cancer" in September 2018, it came six months after her first alert to an abnormality on a routine mammogram and ultrasound. At the time, her biopsy turned up negative for cancer. "I really wanted to believe everything was OK, but I knew something wasn't right," Davis said. At 41 years old, she had no history of cancer. Still, she could feel a lump growing and decided to go for a second opinion and a second biopsy. She was diagnosed with triple-negative breast cancer. Her mind instantly went to her family and three children. "It was very hard to tell them and try and be strong for them," Davis said. "With triple negative, there is nothing for us to take — no pill or anything to prevent recurrence. The rate is high and outcomes are poor if it does come back." After chemotherapy, a double mastectomy and radiation, Davis was finally free of cancer, but she was not free of the fear that lingers. "I was always nervous and afraid of it coming back," she said. So when she learned of an experimental vaccine trial while receiving her cancer care at the Cleveland Clinic, she thought, "What do I have to lose?" "It was something that was going to give me peace of mind," Davis said. "If this could work for me, then I wouldn't have to worry about a recurrence." She became the first woman in the world to take the breast cancer vaccine. A registered nurse herself, what eased her mind was the fact that in years of trials in animals, there had been no cancer recurrence and no anaphylactic reaction. "That was all I needed to hear," said Davis, who reports that in the two years since taking the vaccine, she has never felt better. The vaccine has been studied for more than two decades at the Cleveland Clinic, pioneered by pre-clinical research led by the late Dr. Vincent Tuohy. Inspired by this and what it could mean for the future of cancer diagnosis, Dr. Kumar approached the clinic about developing the vaccine. "I looked at it and I saw the vision," Kumar said. So how does it work? "Is it, in essence, teaching your body not to grow a tumor?" CBS13 reporter Ashley Sharp asked. "That's exactly right. It's teaching your body to destroy the cells that can grow a tumor," Kumar said. If a virus shows up in the body, the immune system teaches itself how to destroy it, knowing, easily, which cells are bad. In cancer, it is more difficult, Dr. Kumar explained. "All of the cells that become cancerous in your body came from normal, healthy cells," Kumar said. "The difference is not big, so the immune system has a harder time recognizing a cancer cell and distinguishing it from a healthy cell." According to the Cleveland Clinic, the vaccine works by targeting a lactation protein called α-lactalbumin, which is no longer found after lactation in normal, aging tissues. It is, however, present in most triple-negative breast cancer patients. If breast cancer develops, the vaccine is designed to instruct the immune system to attack the tumor and keep it from growing entirely. "The results are incredibly promising," Kumar said. "The vision is one day to be able to give this to any woman who wants to prevent cancer from ever occurring in her body. It's a small step and we have many more steps to go, but it's incredible if we can make this happen." It's a promising find for the future of fighting cancer that started with one woman but hopefully ends with every woman. "The bigger picture of this is overwhelming for me," Davis said. The second vaccine trial is set to start in 2024, this time with 600 women instead of 16. This study will be on a much larger scale, where half the women will get the vaccine and the other half will get a placebo. The hope is that within five years, they can get FDA approval to distribute the vaccine to the public. 3 Quote Link to comment Share on other sites More sharing options...
spin_dry Posted December 10, 2023 Share Posted December 10, 2023 Save the tits!!! Quote Link to comment Share on other sites More sharing options...
joe_zrt Posted December 10, 2023 Share Posted December 10, 2023 Why would we go through testing and trials on a new vaccine. How dumb 1 1 Quote Link to comment Share on other sites More sharing options...
Gold Member EvilBird Posted December 10, 2023 Gold Member Share Posted December 10, 2023 Wow thatd be great. Terrible disease that affects far too many Women . 4 1 Quote Link to comment Share on other sites More sharing options...
Voodoo Posted December 10, 2023 Share Posted December 10, 2023 5 hours ago, joe_zrt said: Why would we go through testing and trials on a new vaccine. How dumb Perhaps they should choose a different name, given the drubbing "vaccine" has received in recent years. Quote Link to comment Share on other sites More sharing options...
Mainecat Posted December 10, 2023 Share Posted December 10, 2023 It requires a vaccine? That’s not gonna work. Quote Link to comment Share on other sites More sharing options...
XCR1250 Posted December 10, 2023 Author Share Posted December 10, 2023 7 minutes ago, Mainecat said: It requires a vaccine? That’s not gonna work. Little differant you idiot.. The vaccine has been studied for more than two decades at the Cleveland Clinic, pioneered by pre-clinical research led by the late Dr. Vincent Tuohy. 1 Quote Link to comment Share on other sites More sharing options...
Mainecat Posted December 10, 2023 Share Posted December 10, 2023 2 minutes ago, XCR1250 said: Little differant you idiot.. The vaccine has been studied for more than two decades at the Cleveland Clinic, pioneered by pre-clinical research led by the late Dr. Vincent Tuohy. It prevents unwanted death. Vaccine or no vaccine it’s a choice. Does it work, has it been tested…….was Dr. Fauchi involved? Quote Link to comment Share on other sites More sharing options...
XCR1250 Posted December 10, 2023 Author Share Posted December 10, 2023 8 minutes ago, Mainecat said: It prevents unwanted death. Vaccine or no vaccine it’s a choice. Does it work, has it been tested…….was Dr. Fauchi involved? You are a complete total dummy! 1 Quote Link to comment Share on other sites More sharing options...
Mainecat Posted December 10, 2023 Share Posted December 10, 2023 6 minutes ago, XCR1250 said: You are a complete total dummy! I’ve been told here vaccines are bad. Quote Link to comment Share on other sites More sharing options...
XCR1250 Posted December 10, 2023 Author Share Posted December 10, 2023 (edited) 3 minutes ago, Mainecat said: I’ve been told here vaccines are bad. Link on here that says all vaccines are bad.. Edited December 10, 2023 by XCR1250 1 Quote Link to comment Share on other sites More sharing options...
ICG Posted December 10, 2023 Share Posted December 10, 2023 Wow....it's great, but 16 participant's is too limited to celebrate the end of cancer.... 😢 Sadly, why limit it to 600 cancer victims...it may be a wonder drug ....so, we take it away and the hope of remission to the rest of people suffering from cancer. God, this county is F up with beauracricy and the FDA. Maybe a good political enema to clean out the FDA, and let us have access to anything invented quickly Quote Link to comment Share on other sites More sharing options...
soeaster Posted December 11, 2023 Share Posted December 11, 2023 7 hours ago, ICG said: Wow....it's great, but 16 participant's is too limited to celebrate the end of cancer.... 😢 Sadly, why limit it to 600 cancer victims...it may be a wonder drug ....so, we take it away and the hope of remission to the rest of people suffering from cancer. God, this county is F up with beauracricy and the FDA. Maybe a good political enema to clean out the FDA, and let us have access to anything invented quickly An n-size of 16 patients isn't much of a clinical trial at all. Sounds promising but not much to go on. You'd think it would be a higher priority. in the meantime though, yes, it'll get bogged down with the FDA for the next ? years... Bureaucracy at its finest. Quote Link to comment Share on other sites More sharing options...
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