ford_428cj Posted July 29, 2020 Author Share Posted July 29, 2020 6 minutes ago, frenchy said: but there isn't. Whole slew of Docs in DC yesterday saying there is. Are they lying? Quote Link to comment Share on other sites More sharing options...
Platinum Contributing Member Highmark Posted July 29, 2020 Platinum Contributing Member Share Posted July 29, 2020 Abstract Background Severe acute respiratory syndrome (SARS) is caused by a newly discovered coronavirus (SARS-CoV). No effective prophylactic or post-exposure therapy is currently available. Results We report, however, that chloroquine has strong antiviral effects on SARS-CoV infection of primate cells. These inhibitory effects are observed when the cells are treated with the drug either before or after exposure to the virus, suggesting both prophylactic and therapeutic advantage. In addition to the well-known functions of chloroquine such as elevations of endosomal pH, the drug appears to interfere with terminal glycosylation of the cellular receptor, angiotensin-converting enzyme 2. This may negatively influence the virus-receptor binding and abrogate the infection, with further ramifications by the elevation of vesicular pH, resulting in the inhibition of infection and spread of SARS CoV at clinically admissible concentrations. Conclusion Chloroquine is effective in preventing the spread of SARS CoV in cell culture. Favorable inhibition of virus spread was observed when the cells were either treated with chloroquine prior to or after SARS CoV infection. In addition, the indirect immunofluorescence assay described herein represents a simple and rapid method for screening SARS-CoV antiviral compounds. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1232869/ Quote Link to comment Share on other sites More sharing options...
Platinum Contributing Member Highmark Posted July 29, 2020 Platinum Contributing Member Share Posted July 29, 2020 You guys think Trump just randomly picked Hydroxychloroquine out of hat and promoted it. Quote Link to comment Share on other sites More sharing options...
frenchy Posted July 29, 2020 Share Posted July 29, 2020 7 minutes ago, ford_428cj said: Whole slew of Docs in DC yesterday saying there is. Are they lying? oh you mean the pediatrician, chiropractor, and the witch doctor that are sponsored by the Tea Party Patriots? Them? Seems legit! 1 Quote Link to comment Share on other sites More sharing options...
frenchy Posted July 29, 2020 Share Posted July 29, 2020 1 minute ago, Highmark said: You guys think Trump just randomly picked Hydroxychloroquine out of hat and promoted it. no. I think he spoke far too soon and without thinking of the consequences of what he says, like he always does. Quote Link to comment Share on other sites More sharing options...
Platinum Contributing Member Jimmy Snacks Posted July 29, 2020 Platinum Contributing Member Share Posted July 29, 2020 2 Quote Link to comment Share on other sites More sharing options...
Platinum Contributing Member Highmark Posted July 29, 2020 Platinum Contributing Member Share Posted July 29, 2020 Just now, frenchy said: no. I think he spoke far too soon and without thinking of the consequences of what he says, like he always does. Spoke too soon even though he was right. Which bothers you more....how early he promoted it or the fact he was right? You do understand the history of this drug when looking at effectiveness against similar virus'? Hydroxychloroquine Has about 90 Percent Chance of Helping COVID-19 Patients https://aapsonline.org/hcq-90-percent-chance/ The antiviral properties of these drugs have been studied since 2003. Particularly when combined with zinc, they hinder viral entry into cells and inhibit replication. They may also prevent overreaction by the immune system, which causes the cytokine storm responsible for much of the damage in severe cases, explains AAPS. HCQ is often very helpful in treating autoimmune diseases such as lupus and rheumatoid arthritis. 1 Quote Link to comment Share on other sites More sharing options...
ArcticCrusher Posted July 29, 2020 Share Posted July 29, 2020 2 minutes ago, frenchy said: no. I think he spoke far too soon and without thinking of the consequences of what he says, like he always does. The MSM calling the drug deadly isn't misleading. I mean it wasn't until Trump mentioned it. Quote Link to comment Share on other sites More sharing options...
ArcticCrusher Posted July 29, 2020 Share Posted July 29, 2020 1 minute ago, Highmark said: Spoke too soon even though he was right. Which bothers you more....how early he promoted it or the fact he was right? You do understand the history of this drug when looking at effectiveness against similar virus'? Hydroxychloroquine Has about 90 Percent Chance of Helping COVID-19 Patients https://aapsonline.org/hcq-90-percent-chance/ The antiviral properties of these drugs have been studied since 2003. Particularly when combined with zinc, they hinder viral entry into cells and inhibit replication. They may also prevent overreaction by the immune system, which causes the cytokine storm responsible for much of the damage in severe cases, explains AAPS. HCQ is often very helpful in treating autoimmune diseases such as lupus and rheumatoid arthritis. The bigger question is why are the powers that be letting people die unnecessarily? TDS has gone viral. Quote Link to comment Share on other sites More sharing options...
ArcticCrusher Posted July 29, 2020 Share Posted July 29, 2020 7 minutes ago, frenchy said: oh you mean the pediatrician, chiropractor, and the witch doctor that are sponsored by the Tea Party Patriots? Them? Seems legit! The data backs them though. Quote Link to comment Share on other sites More sharing options...
Platinum Contributing Member Highmark Posted July 29, 2020 Platinum Contributing Member Share Posted July 29, 2020 Just now, ArcticCrusher said: The bigger question is why are the powers that be letting people die unnecessarily? TDS has gone viral. Yep. Many have this idea that the medical community is immune to political opinions. There has never been greater proof that it is not than this. 1 Quote Link to comment Share on other sites More sharing options...
frenchy Posted July 29, 2020 Share Posted July 29, 2020 (edited) 19 minutes ago, Highmark said: Spoke too soon even though he was right. Which bothers you more....how early he promoted it or the fact he was right? You do understand the history of this drug when looking at effectiveness against similar virus'? Hydroxychloroquine Has about 90 Percent Chance of Helping COVID-19 Patients https://aapsonline.org/hcq-90-percent-chance/ The antiviral properties of these drugs have been studied since 2003. Particularly when combined with zinc, they hinder viral entry into cells and inhibit replication. They may also prevent overreaction by the immune system, which causes the cytokine storm responsible for much of the damage in severe cases, explains AAPS. HCQ is often very helpful in treating autoimmune diseases such as lupus and rheumatoid arthritis. you can cherry pick all the studies you want but the simple fact is there is more data out there showing it is ineffective than there is that shows it helps. Far more. And no he was not 'right'. I do laugh at how hard guys like you run cover for him on it though and how determined you are to believe anything positive that is written about it regardless of the source just because you want so badly for trump to be right. Edited July 29, 2020 by frenchy 1 Quote Link to comment Share on other sites More sharing options...
frenchy Posted July 29, 2020 Share Posted July 29, 2020 2 minutes ago, ArcticCrusher said: The data backs them though. no it doesn't. It's laughable to even suggest that. Quote Link to comment Share on other sites More sharing options...
frenchy Posted July 29, 2020 Share Posted July 29, 2020 6 minutes ago, ArcticCrusher said: The MSM calling the drug deadly isn't misleading. I mean it wasn't until Trump mentioned it. it can be deadly when improperly used and taken by those with underlying serious heart conditions, who are over represented as covid patients. Duh. 1 Quote Link to comment Share on other sites More sharing options...
Platinum Contributing Member Highmark Posted July 29, 2020 Platinum Contributing Member Share Posted July 29, 2020 3 minutes ago, frenchy said: you can cherry pick all the studies you want but the simple fact is there is more data out there showing it is ineffective than there is that shows it helps. Far more. And no he was not 'right'. I do laugh at how hard guys like you run cover for him on it though and how determined you are to believe anything positive that is written about it regardless of the source. Exhibit A. Quote Link to comment Share on other sites More sharing options...
frenchy Posted July 29, 2020 Share Posted July 29, 2020 7 minutes ago, ArcticCrusher said: The bigger question is why are the powers that be letting people die unnecessarily? TDS has gone viral. yes, countries across the globe are dismissing it's effectiveness and would prefer their citizens die and economies stay closed because Orange Man Bad. Seems legit. Quote Link to comment Share on other sites More sharing options...
ArcticCrusher Posted July 29, 2020 Share Posted July 29, 2020 21 minutes ago, frenchy said: yes, countries across the globe are dismissing it's effectiveness and would prefer their citizens die and economies stay closed because Orange Man Bad. Seems legit. There is a lot that just doesn't make sense in the world today. Like this. Quote Link to comment Share on other sites More sharing options...
ford_428cj Posted July 29, 2020 Author Share Posted July 29, 2020 44 minutes ago, frenchy said: oh you mean the pediatrician, chiropractor, and the witch doctor that are sponsored by the Tea Party Patriots? Them? Seems legit! Pretty weak ... You didn't answer of they were lying? They went all the way to DC for that eh ... See below ... probably why Michigan hardly has any deaths now from it ... Quote Treatment with Hydroxychloroquine Cut Death Rate Significantly in COVID-19 Patients, Henry Ford Health System Study Shows July 02, 2020 DETROIT – Treatment with hydroxychloroquine cut the death rate significantly in sick patients hospitalized with COVID-19 – and without heart-related side-effects, according to a new study published by Henry Ford Health System. In a large-scale retrospective analysis of 2,541 patients hospitalized between March 10 and May 2, 2020 across the system’s six hospitals, the study found 13% of those treated with hydroxychloroquine alone died compared to 26.4% not treated with hydroxychloroquine. None of the patients had documented serious heart abnormalities; however, patients were monitored for a heart condition routinely pointed to as a reason to avoid the drug as a treatment for COVID-19. The study was published today in the International Journal of Infectious Diseases, the peer-reviewed, open-access online publication of the International Society of Infectious Diseases (ISID.org). Patients treated with hydroxychloroquine at Henry Ford met specific protocol criteria as outlined by the hospital system’s Division of Infectious Diseases. The vast majority received the drug soon after admission; 82% within 24 hours and 91% within 48 hours of admission. All patients in the study were 18 or over with a median age of 64 years; 51% were men and 56% African American. “The findings have been highly analyzed and peer-reviewed,” said Dr. Marcus Zervos, division head of Infectious Disease for Henry Ford Health System, who co-authored the study with Henry Ford epidemiologist Samia Arshad. “We attribute our findings that differ from other studies to early treatment, and part of a combination of interventions that were done in supportive care of patients, including careful cardiac monitoring. Our dosing also differed from other studies not showing a benefit of the drug. And other studies are either not peer reviewed, have limited numbers of patients, different patient populations or other differences from our patients.” Zervos said the potential for a surge in the fall or sooner, and infections continuing worldwide, show an urgency to identifying inexpensive and effective therapies and preventions. “We’re glad to add to the scientific knowledge base on the role and how best to use therapies as we work around the world to provide insight,” he said. “Considered in the context of current studies on the use of hydroxychloroquine for COVID-19, our results suggest that the drug may have an important role to play in reducing COVID-19 mortality.” The study also found those treated with azithromycin alone or a combination of hydroxychloroquine and azithromycin also fared slightly better than those not treated with the drugs, according to the Henry Ford data. The analysis found 22.4% of those treated only with azithromycin died, and 20.1% treated with a combination of azithromycin and hydroxychloroquine died, compared to 26.4% of patients dying who were not treated with either medication. “Our analysis shows that using hydroxychloroquine helped saves lives,” said neurosurgeon Dr. Steven Kalkanis, CEO, Henry Ford Medical Group and Senior Vice President and Chief Academic Officer of Henry Ford Health System. “As doctors and scientists, we look to the data for insight. And the data here is clear that there was benefit to using the drug as a treatment for sick, hospitalized patients.” Overall, hospital system patients in the study experienced an 18.1% in-hospital mortality rate. Regardless of treatment, mortality was highest in: Patients older than 65, Patients who identified as Caucasian, Patients admitted with reduced oxygen levels, Patients who required ICU admission. Patients who died commonly had serious underlying diseases, including chronic kidney and lung disease, with 88% dying from respiratory failure. Globally, the overall mortality from SARS-COV-2 is estimated to be approximately 6% to 7%, with mortality in hospitalized patients ranging between 10% and 30%, according to the study. Mortality as high as 58% has been seen among patients requiring ICU care and mechanical ventilation. According to the U.S. Centers for Disease Control & Prevention, hydroxychloroquine (also known as hydroxychloroquine sulfate) is a U.S. Food & Drug Administration (FDA)-approved arthritis medicine that also can be used to prevent or treat malaria. It is available in the United States by prescription only. The drug is sold under the brand name Plaquenil and it is also sold as a generic medicine. It is commonly used by patients with arthritis, lupus or other rheumatic conditions. Dr. Zervos also pointed out, as does the paper, that the study results should be interpreted with some caution, should not be applied to patients treated outside of hospital settings and require further confirmation in prospective, randomized controlled trials that rigorously evaluate the safety and efficacy of hydroxychloroquine therapy for COVID-19. “Currently, the drug should be used only in hospitalized patients with appropriate monitoring, and as part of study protocols, in accordance with all relevant federal regulations,” Dr. Zervos said. Henry Ford Health System, as one of the region’s major academic medical centers with more than $100 million in annual research funding, is involved in numerous COVID-19 trials with national and international partners. Henry Ford Health System is currently also involved in a prophylactic hydroxychloroquine study: “Will Hydroxychloroquine Impede or Prevent COVID-19,” or WHIP COVID-19. The study is a 3,000-person, randomized, double-blinded look at whether hydroxychloroquine prevents healthcare and frontline workers from contracting the COVID-19 virus. The WHIP COVID-19 team is working on expanding study sites while there is a lull in the number of COVID-19 cases in Southeast Michigan. This is in preparation for a potential increase of COVID-19 cases as Fall flu season approaches, with additional sites available for convenient enrollment of healthcare workers and first responders. The WHIP COVID-19 team is also taking this gift of time to reach out to other areas of the world that are seeing a blossoming of cases: Brazil and Argentina. There are currently 619 people enrolled in the study, out of a target of 3,000. ### About Henry Ford Health System: Under the leadership of President and CEO Wright L. Lassiter, III, Henry Ford Health System is a $6.5 billion integrated health system comprised of six hospitals, a health plan, and 250+ sites including medical centers, walk-in and urgent care clinics, pharmacy, eye care facilities and other healthcare retail. Established in 1915 by auto industry pioneer Henry Ford, the health system now has 32,000 employees and remains home to the 1,900-member Henry Ford Medical Group, one of the nation’s oldest physician groups. An additional 2,200 physicians are also affiliated with the health system through the Henry Ford Physician Network. An active participant in medical education and training, the health system has trained nearly 40% of physicians currently practicing in the state and also provides education and training for other health professionals including nurses, pharmacists, radiology and respiratory technicians. Media contact email: MediaRelations@hfhs.org 40 minutes ago, Highmark said: Spoke too soon even though he was right. Which bothers you more....how early he promoted it or the fact he was right? You do understand the history of this drug when looking at effectiveness against similar virus'? Hydroxychloroquine Has about 90 Percent Chance of Helping COVID-19 Patients https://aapsonline.org/hcq-90-percent-chance/ The antiviral properties of these drugs have been studied since 2003. Particularly when combined with zinc, they hinder viral entry into cells and inhibit replication. They may also prevent overreaction by the immune system, which causes the cytokine storm responsible for much of the damage in severe cases, explains AAPS. HCQ is often very helpful in treating autoimmune diseases such as lupus and rheumatoid arthritis. Bold ... little Frenchy has gotten the TDS no doubt Quote Link to comment Share on other sites More sharing options...
Platinum Contributing Member Jimmy Snacks Posted July 29, 2020 Platinum Contributing Member Share Posted July 29, 2020 Dr. Zervos also pointed out, as does the paper, that the study results should be interpreted with some caution, should not be applied to patients treated outside of hospital settings and require further confirmation in prospective, randomized controlled trials that rigorously evaluate the safety and efficacy of hydroxychloroquine therapy for COVID-19. “Currently, the drug should be used only in hospitalized patients with appropriate monitoring, and as part of study protocols, in accordance with all relevant federal regulations,” Dr. Zervos said. Which is why Trump should not have told the American people that he was taking it like he was eating gummy bears...if that was even true. Quote Link to comment Share on other sites More sharing options...
ArcticCrusher Posted July 29, 2020 Share Posted July 29, 2020 9 minutes ago, Jimmy Snacks said: Dr. Zervos also pointed out, as does the paper, that the study results should be interpreted with some caution, should not be applied to patients treated outside of hospital settings and require further confirmation in prospective, randomized controlled trials that rigorously evaluate the safety and efficacy of hydroxychloroquine therapy for COVID-19. “Currently, the drug should be used only in hospitalized patients with appropriate monitoring, and as part of study protocols, in accordance with all relevant federal regulations,” Dr. Zervos said. Which is why Trump should not have told the American people that he was taking it like he was eating gummy bears...if that was even true. I agree with that, however the bigger question is why they are saying it doesn't work and should not even be considered as a treatment when the data clearly supports it? Quote Link to comment Share on other sites More sharing options...
Platinum Contributing Member Highmark Posted July 29, 2020 Platinum Contributing Member Share Posted July 29, 2020 1 hour ago, frenchy said: oh you mean the pediatrician, chiropractor, and the witch doctor that are sponsored by the Tea Party Patriots? Them? Seems legit! I'll take the word of the Yale professor of epidemiology over yours. https://justthenews.com/politics-policy/coronavirus/yale-epidemiologist-says-hydroxychloroquine-key-defeating-covid-19 https://medicine.yale.edu/profile/harvey_risch/ Quote Link to comment Share on other sites More sharing options...
frenchy Posted July 29, 2020 Share Posted July 29, 2020 (edited) 29 minutes ago, ford_428cj said: Pretty weak ... You didn't answer of they were lying? They went all the way to DC for that eh ... See below ... probably why Michigan hardly has any deaths now from it ... Bold ... little Frenchy has gotten the TDS no doubt right from your study: Treatment with hydroxychloroquine cut the death rate significantly in sick patients hospitalized with COVID-19 – and without heart-related side-effects. In a large-scale retrospective analysis of 2,541 patients hospitalized between March 10 and May 2, 2020 across the system’s six hospitals, the study found 13% of those treated with hydroxychloroquine alone died compared to 26.4% not treated with hydroxychloroquine. Those not treated with it all had underlying heart conditions which is the greatest at risk group for covid fatality and that alone puts them at a far greater risk of dying. Greater than the 13.4% difference in fatality rates. Rendering said study.....essentially worthless. Poor ford. So gullible. Edited July 29, 2020 by frenchy Quote Link to comment Share on other sites More sharing options...
Platinum Contributing Member Highmark Posted July 29, 2020 Platinum Contributing Member Share Posted July 29, 2020 1 minute ago, frenchy said: right from your study: In a large-scale retrospective analysis of 2,541 patients hospitalized between March 10 and May 2, 2020 across the system’s six hospitals, the study found 13% of those treated with hydroxychloroquine alone died compared to 26.4% not treated with hydroxychloroquine. Those not treated with it all had severe underlying heart conditions which alone puts them at a far greater risk of dying. Greater than the 13.4% difference in fatality rates. Rendering said study.....essentially worthless. Poor ford. So gullible. Holy fuck dude you don't think a 50% reduction in fatalities significant? Well now I understand the problem here. Quote Link to comment Share on other sites More sharing options...
frenchy Posted July 29, 2020 Share Posted July 29, 2020 (edited) 4 minutes ago, Highmark said: Holy fuck dude you don't think a 50% reduction in fatalities significant? Well now I understand the problem here. not when the greatest at risk group for death is omitted from your sample group but kept in the group stats for those who did not take it. DUHHHHHH! Edited July 29, 2020 by frenchy Quote Link to comment Share on other sites More sharing options...
ford_428cj Posted July 29, 2020 Author Share Posted July 29, 2020 5 minutes ago, frenchy said: right from your study: Treatment with hydroxychloroquine cut the death rate significantly in sick patients hospitalized with COVID-19 – and without heart-related side-effects. In a large-scale retrospective analysis of 2,541 patients hospitalized between March 10 and May 2, 2020 across the system’s six hospitals, the study found 13% of those treated with hydroxychloroquine alone died compared to 26.4% not treated with hydroxychloroquine. Those not treated with it all had underlying heart conditions which is the greatest at risk group for covid fatality and that alone puts them at a far greater risk of dying. Greater than the 13.4% difference in fatality rates. Rendering said study.....essentially worthless. Poor ford. So gullible. Man you are looking like a clown ... Some of them were 90+ yrs old you fool & had underlying conditions. Can't save everyone ...especially people that are already on deaths doorstep. 8 minutes ago, Highmark said: I'll take the word of the Yale professor of epidemiology over yours. https://justthenews.com/politics-policy/coronavirus/yale-epidemiologist-says-hydroxychloroquine-key-defeating-covid-19 https://medicine.yale.edu/profile/harvey_risch/ Quote Link to comment Share on other sites More sharing options...
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