2 weeks, wow

[XCR1250]

With pancreatic cancer ranking as one of the most deadly forms of cancer, researchers are excited to report on a promising new breakthrough for a treatment.

Pancreatic cancer, which maintains a 95% mortality rate, is resistant to all current treatments. Patients have extremely poor chances of surviving for five years after being diagnosed—and since the disease does not show symptoms until the advanced stages, it is notoriously hard to diagnose.

However, this new Tel Aviv University study finds that a small molecule has the ability to induce the self-destruction of pancreatic cancer cells. The research was conducted with xenografts—transplantations of human pancreatic cancer into immunocompromised mice. The treatment reduced the number of cancer cells by 90% in the developed tumors a month after being administered.

 

The research holds great potential for the development of a new effective therapy to treat this aggressive cancer in humans.

WATCH: He Was Called Foolish for His Research; Now Documentary Tells How He Won Nobel Prize for ‘Cancer Cure’

The study, which was published in the journal Oncotarget, was led by Professor Malca Cohen-Armon and her team at TAU’s Sackler Faculty of Medicine, in collaboration with Dr. Talia Golan’s team at the Cancer Research Center at Sheba Medical Center.

“In research published in 2017, we discovered a mechanism that causes the self-destruction of human cancer cells during their duplication without affecting normal cells,” explains Prof. Cohen-Armon. “We have now harnessed this information to efficiently eradicate human pancreatic cancer cells in xenografts. The current results were obtained using a small molecule that evokes this self-destruction mechanism in a variety of human cancer cells.

“The mice were treated with a molecule called PJ34, which is permeable in the cell membrane, but affects human cancer cells exclusively. This molecule causes an anomaly during the duplication of human cancer cells, provoking their rapid cell death. Thus, cell multiplication itself resulted in cell death in the treated cancer cells.”

RELATED: Boy is Cured of Aggressive Cancer Thanks to Stem Cell Treatment Using Donated Umbilical Cord

A month after being injected with PJ34 daily for 14 days, the pancreatic cancer cells in the tumors of the treated mice experienced a relative drop of 90%. In one mouse, the tumor completely disappeared.

“It is important to note that no adverse effects were observed, and there were no changes in the weight gain of the mice, nor in their behavior,” says Professor Cohen-Armon.

This mechanism acts efficiently in other types of cancer resistant to current therapies. The molecule PJ34 is being tested in pre-clinical trials according to FDA regulations before clinical trials begin.

Reprinted from Tel Aviv University

In trial on mice, molecule used to treat stroke killed 90% of infected cells, leaving healthy ones untouched

In a potential breakthrough, an Israeli research group has developed a treatment for pancreatic cancer that results in 90% of cancerous cells being eradicated in just two weeks.

The research group, led by Professor Malka Cohen-Armon from Tel Aviv University, and Dr. Talia Golan from the Sheba Medical Center in Ramat Gan, devised a novel way to use the PJ34 molecule, originally developed to treat stroke.

When injected intravenously in mice with transplanted pancreatic cancer, the molecule caused cancerous cells to die during mitosis - a multiplication process in which one cell splits into two.

Importantly, the treatment only seemed to affect the infected cells, as Professor Malka Cohen-Armon told i24NEWS's Jeff Smith, host of the Daily Dose.

 

 

 

Israeli scientists make breakthrough in cancer research | 03.12.2019

 

 

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The ability to target only the infected cells is the Holy Grail for cancer treatment researchers, as the current chemotherapy drugs tend to affect the healthy cells as well.

This indiscriminate approach takes a heavy toll on the patient's organism, often prompting them to give up the treatment; recently, however, Israeli researchers came up with another way to solve this issue. 

Pancreatic cancer is one of the worst forms of this disease in terms of survival rates, with only about 5% of patients living for more than five years after being diagnosed with it.

In 2018, it caused a total of 432,242 deaths, being ranked the 11th most common cancer in the world.

 

 

 

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Edited December 4, 2019 by XCR1250

[Kivalo]

Cancer is a bitch of a disease.

[DriftBusta]

Thats great news.  I have an elderly lady client who’s had it now for about a year, done with chemo for now, on some pills but she says she feels good. Another friend has had what was originally diagnosed as stage 4 lung cancer, that normally would have killed him in a year.  But hes on some trial and hasn’t had a sick day in the 5 years he’s had.  Sloan Kettering just told him that he only needs to come every 4 months instead of every 3 now.  Some pretty amazing advances.  Also hearing the same for Alzheimers, which took our dad 10 years ago.  

[f7ben]

Either they will shelf it or it will cost 10 million dollars. The fda will make of it 

Edited December 4, 2019 by f7ben

[BOHICA]

The way democrats are isolating Israel I doubt they we share with us their break through

[f7ben]

4 minutes ago, BOHICA said:

The way democrats are isolating Israel I doubt they we share with us their break through

Like they were going to give it to us free of charge anyway fucking moron 

[BOHICA]

Just now, f7ben said:

Like they were going to give it to us free of charge anyway fucking moron 

Unlikely it would be free but wonder if the US would even have access to it with they way some US people treat Israel.  I wouldn’t blame Israel at this point if they choose to restrict access of US citizens to this treatment potential or charging astronomical prices for it.

[f7ben]

3 minutes ago, BOHICA said:

Unlikely it would be free but wonder if the US would even have access to it with they way some US people treat Israel.  I wouldn’t blame Israel at this point if they choose to restrict access of US citizens to this treatment potential or charging astronomical prices for it.

Derpy herp derp