akvanden Posted July 29, 2021 Share Posted July 29, 2021 Fascinating read and speaks to the complexity of COVID and why it's novel. Doesn't say anything about vaccinations, so no need to worry. Just an interesting read. https://www.nature.com/articles/d41586-021-02039-y Quote Link to comment Share on other sites More sharing options...
Platinum Contributing Member Jimmy Snacks Posted July 29, 2021 Platinum Contributing Member Share Posted July 29, 2021 Excellent read and quite fascinating.👍🏼 Quote Link to comment Share on other sites More sharing options...
Plissken Posted July 29, 2021 Share Posted July 29, 2021 Really good article. The animations and high level detail of the spike proteins are fascinating. Also, this: The virus’s speedy entry using TMPRSS2 explains why the malaria drug chloroquine didn’t work in clinical trials as a COVID-19 treatment, despite early promising studies in the lab10. Those turned out to have used cells that rely exclusively on cathepsins for endosomal entry. “When the virus transmits and replicates in the human airway, it doesn’t use endosomes, so chloroquine, which is an endosomal disrupting drug, is not effective in real life,” says Barclay. 2 Quote Link to comment Share on other sites More sharing options...
DriftBusta Posted July 29, 2021 Share Posted July 29, 2021 2 hours ago, Plissken said: Really good article. The animations and high level detail of the spike proteins are fascinating. Also, this: The virus’s speedy entry using TMPRSS2 explains why the malaria drug chloroquine didn’t work in clinical trials as a COVID-19 treatment, despite early promising studies in the lab10. Those turned out to have used cells that rely exclusively on cathepsins for endosomal entry. “When the virus transmits and replicates in the human airway, it doesn’t use endosomes, so chloroquine, which is an endosomal disrupting drug, is not effective in real life,” says Barclay. Fucking English please. Quote Link to comment Share on other sites More sharing options...
Platinum Contributing Member Highmark Posted July 29, 2021 Platinum Contributing Member Share Posted July 29, 2021 MMMMM.....a pangolin kissed a turtle? Maybe a bat flew into the cloaca of a turkey and then it sneezed into my chili and now we all have coronavirus? Quote Link to comment Share on other sites More sharing options...
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