Platinum Contributing Member Jimmy Snacks Posted May 5, 2020 Platinum Contributing Member Share Posted May 5, 2020 My brother the Trumper sent me this...hmmm... Quote Link to comment Share on other sites More sharing options...
Platinum Contributing Member Highmark Posted May 5, 2020 Platinum Contributing Member Share Posted May 5, 2020 Its been know for a long time to have some effect on versions of coronavirus'. Published in 2005 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1232869/ Background Severe acute respiratory syndrome (SARS) is caused by a newly discovered coronavirus (SARS-CoV). No effective prophylactic or post-exposure therapy is currently available. Results We report, however, that chloroquine has strong antiviral effects on SARS-CoV infection of primate cells. These inhibitory effects are observed when the cells are treated with the drug either before or after exposure to the virus, suggesting both prophylactic and therapeutic advantage. In addition to the well-known functions of chloroquine such as elevations of endosomal pH, the drug appears to interfere with terminal glycosylation of the cellular receptor, angiotensin-converting enzyme 2. This may negatively influence the virus-receptor binding and abrogate the infection, with further ramifications by the elevation of vesicular pH, resulting in the inhibition of infection and spread of SARS CoV at clinically admissible concentrations. Conclusion Chloroquine is effective in preventing the spread of SARS CoV in cell culture. Favorable inhibition of virus spread was observed when the cells were either treated with chloroquine prior to or after SARS CoV infection. In addition, the indirect immunofluorescence assay described herein represents a simple and rapid method for screening SARS-CoV antiviral compounds. Quote Link to comment Share on other sites More sharing options...
Platinum Contributing Member Highmark Posted May 5, 2020 Platinum Contributing Member Share Posted May 5, 2020 From 2003 https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(03)00806-5/fulltext Quote Link to comment Share on other sites More sharing options...
spin_dry Posted May 5, 2020 Share Posted May 5, 2020 It doesn’t work. But it made a good movie plot. Quote Link to comment Share on other sites More sharing options...
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