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How the coronavirus infects cells


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Really good article.  The animations and high level detail of the spike proteins are fascinating.  
 

Also, this:  

The virus’s speedy entry using TMPRSS2 explains why the malaria drug chloroquine didn’t work in clinical trials as a COVID-19 treatment, despite early promising studies in the lab10. Those turned out to have used cells that rely exclusively on cathepsins for endosomal entry. “When the virus transmits and replicates in the human airway, it doesn’t use endosomes, so chloroquine, which is an endosomal disrupting drug, is not effective in real life,” says Barclay.

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2 hours ago, Plissken said:

Really good article.  The animations and high level detail of the spike proteins are fascinating.  
 

Also, this:  

The virus’s speedy entry using TMPRSS2 explains why the malaria drug chloroquine didn’t work in clinical trials as a COVID-19 treatment, despite early promising studies in the lab10. Those turned out to have used cells that rely exclusively on cathepsins for endosomal entry. “When the virus transmits and replicates in the human airway, it doesn’t use endosomes, so chloroquine, which is an endosomal disrupting drug, is not effective in real life,” says Barclay.

Fucking English please.

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MMMMM.....a pangolin kissed a turtle?  

Maybe a bat flew into the cloaca of a turkey and then it sneezed into my chili and now we all have coronavirus?

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